Bioavailability

Why You Can’t Just Purchase Rapamycin from a Chemical Supplier and Expect It to Work

1. Bioavailability Challenges

Raw rapamycin has extremely poor water solubility and low oral bioavailability, meaning that if you simply ingest it in powder form, your body will struggle to absorb it effectively. Prescription rapamycin formulations, such as Rapamune, are specifically designed with advanced carriers and excipients to improve absorption and ensure that the drug reaches therapeutic levels in the bloodstream.

Scientific research confirms this, and our own firsthand experience supports it—raw rapamycin powder simply does not work when taken orally. Cheap, unformulated rapamycin from chemical suppliers, particularly those from low-quality sources, will likely have little to no physiological effect due to its poor bioavailability.

2. The Importance of Pharmaceutical-Grade Rapamycin

We only use human-grade, pharmacy-manufactured rapamycin in film-coated tablet form because of its superior bioavailability and consistent potency. Through extensive testing, we have found that compounded rapamycin capsules, whether standard or enteric-coated (acid-resistant), fail to deliver reliable absorption.

For example, a 10mg dose of rapamycin in an enteric-coated capsule did not even register on blood tests. This suggests that compounded rapamycin, despite its formulation attempts, remains largely ineffective compared to pharmaceutical-grade options.

The pharmacy-grade 2mg rapamycin tablets we stock are of the highest quality, ensuring reliable absorption and effectiveness.

3. A Cost-Effective Alternative: Transdermal Rapamycin

For those looking for a more affordable yet highly effective alternative, our transdermal rapamycin cream is an excellent choice. This formulation bypasses the digestive system entirely, eliminating the bioavailability issues associated with oral administration. Instead, the rapamycin is delivered directly into systemic circulation through the skin.

Our transdermal cream is formulated using the same advanced pharmaceutical-grade base used in hormone replacement therapy (HRT), ensuring optimal absorption and effectiveness. This makes it a superior option for those seeking reliable rapamycin delivery without the challenges of oral administration.